Old architectures in Thanh Ha - Bao Vinh area

VĂN HÓA - LỊCH SỬ HUẾ QUA GÓC NHÌN LÀNG XÃ PHỤ CẬN VÀ QUAN HỆ VỚI BÊN NGOÀI 　フエの文化と歴史：周辺集落と外部との関係からの視点より　Session 1: Huong Vinh Land with town-harbour Thanh Ha-Bao Vin

CONCEPT GENERATION SUPPORT BY CONCEPTUAL BLENDING: MULTI-AREA INSPIRATION SEARCH

Master'sMASTER OF ENGINEERIN

Effect of Pharmacist-Led Interventions on Physicians' Prescribing for Pediatric Outpatients

BACKGROUND: Children are at high risk of drug-related problems, increased risk of treatment failures, and high treatment costs. We aimed to evaluate the effect of pharmacist-led interventions on physicians' prescribing for pediatric outpatients. METHODS: A prospective study with pre- and post-intervention measurement assessment was conducted to collect pediatric outpatients' prescriptions during the pre-intervention period (January 2020) and post-intervention (August 2020) at a children's hospital in Vietnam. Drug-related problems were identified and categorized according to Pharmaceutical Care Network Europe (PCNE), version 9.1. The intervention program was developed based on the results of pre-intervention observations. After the intervention, prescriptions were evaluated. Statistical tests were used to compare the proportions of drug-related problems before and after the intervention and to identify factors related to drug-related problems. RESULTS: There were 2788 out of 4218 (66.1%) prescriptions with at least one drug-related problem before the intervention. Of these drug-related problems, the most common was inappropriate timing of administration and incorrect dosage (36.1% and 35.6%, respectively). After the intervention, the percentage of prescriptions with at least one drug-related problem was 45.5% (p < 0.001). Most of the drug-related problem types decreased significantly (p < 0.05). The binary logistic regression analysis results showed that in addition to pharmacists' intervention, patients' gender, primary disease, comorbidity status, and the total number of drugs prescribed were also factors related to drug-related problems. CONCLUSIONS: Drug-related problems in pediatric outpatients were quite common. Pharmacists' intervention helped to improve the prevalence and types of drug-related problems

Arbitrary Form Plasmonic Structures: Optical Realization, Numerical Analysis and Demonstration Applications

Surface plasmon resonance has attracted more and more attention thanks to its wide range of applications in numerous fields (physics, chemistry, biology, etc.). In this chapter, we present different aspects, from theoretical calculation and experimental fabrication to applications demonstration, related to arbitrary shape plasmonic nanostructures. First, numerical calculations based on finite-difference time-domain method were realized to investigate the plasmonic properties of gold nanostructures having various size and shapes. Then the direct laser writing method was demonstrated as an excellent tool for fabrication on demand of arbitrary nanostructures. Plasmonic structures were obtained indirectly by a standard lift-off method from a polymeric template and directly by tightly focusing a continuous-wave laser beam onto a metallic thin film. Finally, demonstration of various applications of fabricated plasmonic structures, namely plasmonic-based data storage, color nanoprinter, tunable filters, and plasmonic-magneto-optics sensors will be shown

Synthesis and Characterization of Silver Nanoplates by a Seed-mediated Method

Silver nanoplates (SNPs) having different size were synthesized by a seed-mediated method. The seeds -silver nanoparticles with 4 – 6 nm diameters were synthesized first by reducing silver nitrate with sodium borohydride in the present of Trisodium Citrate and Hydrogen peroxide. Then these seeds were developed by continue reducing Ag$^+$ ions with various amount of L-Ascorbic acid to form SNPs. Our analysis showed that the concentratrion of L-Ascorbic acid, a secondary reducing agent, played an important role to form SNPs. In addition, the size and in-plane dipole plasmon resonance wavelenght of silver nanoplates were increased when the concentration of added silver nitrate increased. The characterization of SNPs were studied by UV-Vis, FE-SEM, EDS and TEM methods

A preliminary study to establish the transfected CHO cell lines which highly express Trastuzumab - A biosimilar product of Herceptin

Human epidermal growth factor receptor 2 (HER2) has been identified as a molecular target for breast cancer therapy, such as Trastuzumab (Herceptin®). This has been shown to improve patient survival substantially. The current study is aiming to locally produce an anti-HER2 monoclonal antibody (named Trastuzumab) which has an equivalent biological properties in comparison with the original version, Herceptin®). In silico design and construction of recombinant vectors, as well as the establishment of transfected cell lines with high expression of Trastuzumab were performed. Based on the protein sequences obtained from the Drugbank, the DNA sequences encoding for the light chain (Tras-Lc) and heavy chain (Tras-Hc) of Trastuzumab were optimized and integrated into pNanogen-Hygro and pNanogen-Puro vectors, respectively. The Neon Transfection System was used to co-transfect the pNanogen-Tras-Lc-Hygro and pNanogen-Tras-Hc-Puro constructs into CHO cells. Different co-transfected single-cell-colonies selected on media supplemented with hygromycin and puromycin were used for ELISA and SDS-PAGE assays to identify the CHO cell lines which highly express Trastuzumab. Based on the present results, 30μg of both constructs were suitable for DNA co-transfection. After 07 days of culture, the highest amount of Trastuzumab (561 µg/ml) was obtained from the H06LD68 cell line

Structure elucidation off seven steroids from Sinularia conferta.

Seven steroids were isolated from the methanol extract of the soft corals Sinularia conferta. These steroids were elucidated as 7a-methoxyergosta-5,24(28)-diene-3b-ol (1), ergosta-5-ene-3β,7α-diol (2), 3β,7α-dihydroxyergosta-5,24(28)-diene (3), 3β-hydroxyergosta-5,24(28)-diene-7-one (4), ergosta-24(28)-ene-3β,5α,6β-triol-6-acetate (5), ergosta-24(28)-ene-3β,5α,6β-triol (6), and ergosta-3β,5α,6β-triol (7) by 1D and 2D-NMR experiments and comparison with reported data. Keywords. Sinularia conferta, Alcyoniidae, soft coral, steroid

Late Pleistocene-Holocene sequence stratigraphy of the subaqueous Red River delta and the adjacent shelf

The model of Late Pleistocene-Holocene sequence stratigraphy of the subaqueous Red River delta and the adjacent shelf is proposed by interpretation of high-resolution seismic documents and comparison with previous research results on Holocene sedimentary evolution on the delta plain. Four units (U1, U2, U3, and U4) and four sequence stratigraphic surfaces (SB1, TS, TRS and MFS) were determined. The formation of these units and surfaces is related to the global sea-level change in Late Pleistocene-Holocene. SB1, defined as the sequence boundary, was generated by subaerial processes during the Late Pleistocene regression and could be remolded partially or significantly by transgressive ravinement processes subsequently. 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